European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS AND EVALUATION OF ANTIMITOTIC ACTIVITY OF NEW TETRALONE ACIDS

Raju D, Y. B. Basavaraju*, Hemant Kumar, Umesha B and Nandini K

ABSTRACT

The new tetralone acid intermediates were synthesized in high yields for analogues of podophyllotoxin by Gensler’s method with slight change in reagents and experimental procedure. All the synthesised compounds were characterized by spectral and elemental analysis data. The synthesized new compounds were evaluated for antimitotic activity by onion root tip method. The synthesized analogues showed strong to moderate activity. The antimitotic activity was compared with control, the compounds 13e and 13f were showed good inhibition of normal cell devision and compounds 13a and 13c exhibited less inhibition while the compounds 13b and 13d exhibited moderate activity.

Keywords: Ketones, Itaconic acids, Tetralone acds, Gensler’s method, Stobbe condensation, Catalytic hydrogenation, Antimitotic activity.