Abstract
GASTROPROTECTIVE ACTIVITY OF BROWN PROPOLIS EXTRACT AGAINST ASPIRIN AND ETHANOL- INDUCED GASTRIC ULCERS IN ADULT WISTAR RATS BY TARGETING OXIDATIVE STRESS AND PRO-INFLAMMATORY SIGNALING

Mrunal Patil and Kedar Prabhavalkar*

ABSTRACT

Aspirin is a commonly prescribed non steroidal anti-inflammatory drug and alcohol is consumed by large number of population throughout the world but its prolonged use injures the gastric mucosa. This study was carried out to investigate the therapeutic effect of Brown Propolis Extract (BPE) against aspirin and ethanol- induced gastric ulcers in Wistar rats. Gastric ulcer was induced by oral administration of aspirin (200 mg/kg/day) for 3 days. Pretreatment with BPE (250 and 500 mg/kg bw) was given orally for 10 days. Ranitidine at 50 mg/kg orally was used as standard. The various parameters like gastric volume, gastric pH, free acidity, total acidity, ulcer index, percent inhibition were estimated for assessment of anti-secretory and gastroprotective effects of BPE. At the same time antioxidant parameters like superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) and reduced glutathione (GSH) in addition to that pro-inflammatory parameters such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) were also estimated according to their respective method of estimation using analyzing kit. BPE helped in improving the gross morphology, histology and mucous layer of gastric tissue, antioxidants and by reducing tissue levels of the lipid peroxidation marker (malondialdehyde) and inflammatory mediators. In conclusion, BPE has a therapeutic potential in aspirin and ethanol- induced gastric injury by alleviating oxidative stress and inflammation.

Keywords: Brown Propolis Extract, gastric ulcers, pro-inflammatory, antioxidant, malondialdehyde.


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