European Journal of Biomedical and Pharmaceutical Sciences

NEUROPROTECTIVE AND ANTIANXIETY POTENTIALS OF MIMUSOPS ELENGI IN MICE

*Charan C. S.

ABSTRACT

Introduction: Anxiety is one of the most disabling features of many disorders, impairing the normal daily activities of the patients and profoundly affecting their families. The current study was undertaken to ascertain the effects of MIMUSOPS ELENGIas ananxiolytic agent. Materials and Methods: Elevated plus maze, Light and Dark box Test and Open field test were employed to evaluate acquisition and retention parameters. MIMUSOPS ELENGI(250 & 500 mg/kg, p.o.) was administered to both young and aged mice. Result: MIMUSOPS ELENGI(250 & 500 mg/kg, p.o.) significantly improved acquisition and retention in young mice and also reversed the anxiety induced by diazepam (1 mg/kg, i.p.), and scopolamine (0.4 mg/kg, i.p.). MIMUSOPS ELENGI(250 & 500 mg/kg, p.o.) was found to possess potential anti-anxiety effects. Conclusion: MIMUSOPS ELENGIcan be a useful as a potential Neuroprotective and Anxiolytic agent.

Keywords: MIMUSOPS ELENGI, Acquisition, Retention, Anxiety.