Abstract
NANOSPONGES: A NOVEL COLLOIDAL CARRIER FOR TARGET DRUG DELIVERY

Prasanthi*, Sravani B, Padmalatha K.

ABSTRACT

Targeted delivery of drugs and enhancement of bioavailability of poorly water soluble drugs are the two main challenges encountered by the researchers for the design of safe and effective dosage form. Nanotechnology has gained significance in the design of controlled drug delivery with minimum side effects and achieves maximum therapeutic action at low doses. Nanosponges are novel colloidal carrier particles with a 3-dimensional network and a nanometric cavity size that can entangle drugs and then be formulated into a suitable dosage form based up on the route of administration. After administration of nanosponges, they circulate along with blood around the body until they come across the specific target site and bound to the surface and liberate the drug in a controlled and predictable manner. Both lipophilic and hydrophilic drugs can be encapsulated in nanoporous cavities of nanosponges. The advantages of nanosponges includes they avoid degradation of drugs and proteins; provide sustained drug release at the target site, increase aqueous solubility of low water-soluble drugs. Particle size of nanosponges depends upon proportion of the amount of crosslinker to the polymer. They are prepared by different methods such as solvent diffusion method, emulsion solvent diffusion method, ultrasound-assisted method and quasi emulsion solvent diffusion method. They possess the ability of delivery of active ingredients into oral, topical, parenteral, and nasal routes make them a superior candidate for targeted and local action. It can be used as a carrier for biocatalysts and in delivery of enzymes, proteins, vaccines and antibodies.

Keywords: Nanosponges, Crosslinkers, ?- Cyclodextrin and Emulsion diffusion method.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW AUGUST ISSUE PUBLISHED

    AUGUST 2020 Issue has been successfully launched on 1 August 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT