European Journal of Biomedical and Pharmaceutical Sciences

MYSTERY OF OBNOXIOUS SMELLING DIAMINO ALKANE VOLATILE GASES: CADAVER, CADAVERINE AND PUTRESCINE

Subham Chakraborty*, Joyeta Ghosh, Dhrubajyoti Bardhan, Arpita Biswas, Dr. Dhrubo Jyoti Sen, Dr. Beduin Mahanti

ABSTRACT

Diamino alkanes in volatile species: Cadaver, Cadaverine and Putrescine gases: Do you know what are diamino alkanes volatile gases? Basically, these are obnoxious smelling volatile gases, Cadavers are liberated from deadly human bodies or decomposed matters. Cadavers are volatile gases and are used by Medical Students for studying the anatomy, to identify disease sites and to determine the cause of deaths. These gases are obtained from unclaimed bodies i.e., those who died without any witnesses and discovered by two ancient Greece scientists Herophilon of Chalcedon and Erasistratus of Ceos. Maximum students use Cadavers for suturing each body part of dead bodies and lastly, they are returned to their family for cremation. Infectious Pathogens in Cadavers include tuberculosis, Hepatitis B, HIV etc., and the chemicals like formaldehyde, phenol, methanol and glycerine are used to preserve Cadavers. Cadaverine are alpha alkane, omega diamine straight chain core with amino substituents at 1st and 5th positions. It was discovered by Berlin Physicians in 1885. For microbial fermentation, Cadaverine strains are engineered by L-Lysine. Lysine is decarboxylated to Cadaverine in the presence of enzyme Lysine decarboxylase. It has tremendous effects on plants and animals and shows its large toxicity range. Cadaverine found in some plants in trace amount to attract strangers and acts as a tool for training search and dogs. Different diseases for cadaverine gases are Kidney disease, Leukaemia etc. and EMT gene is regulated upon its treatment. Whereas, Putrescine is a four-carbon alkane omega diamine, obtained by amino acid breakdown and have foul odour of putrefying fish. This gas has high toxicity range when decomposed, it releases fumes of NOx. It plays multifunctional role in cell-growth, differentiation, and cell growth. Polyamines also play role in cellular processes, migration and mucosal maturation. Putrescine also influences RNA stabilization and transitional frame-shifting.

Keywords: Cadaver-graft, bio-based polyamides, microbial fermentation, amino acid breakdown, selfdigestion, bloating, putrefaction, unclaimed bodies, warranted, Plastination, polymerization reaction, Metabolism, Anaerobiosis, biosynthesis, Methionine, Duraboline, T