Abstract
PREPARATION AND EVALUATION OF MICROPARTICLES CONTAINING CYCLOPHOSPHAMIDE FOR CONTROLLED RELEASE

*Nagendra R.

ABSTRACT

The present study aimed at preparation and Evaluation of microparticles for controlled release of Cyclophosphamide using blend of polymers in the treatment of Cancer. The microparticles of Cyclophosphamide were prepared by spray drying technique .The prepared microparticles were evaluated for drug polymer compatibility, the results shown that there were no significant interactions. The encapsulation efficacy was ranging from 69-90%. The in-vitro drug release studies indicate the release of drug in a controlled manner over a period of 12 hrs. It was found that the Cyclophosphamide release rate increased with a decreased amount of polymers. This can be adjusted by maintaining the concentration of the polymers. The formulation FD1 was found to be optimum formulation.

Keywords: Cyclophosphamide, Cancer, spray drying, Controlled release.


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