European Journal of Biomedical and Pharmaceutical Sciences

FREQUENCY OF SILENT MYOCARDIAL ISCHEMIA IN PATIENTS WITH DIABETIC NEPHROPATHY

Dr. Saba Nadeem*, Dr. Bisma Tabusum and Dr. Farah Abbas

ABSTRACT

Introduction: As silent myocardial ischemia (SMI) is more common in diabetic population leading to the development of future coronary artery disease, so its early diagnosis is important. This study was conducted to determine the frequency of silent myocardial ischemia in Type 2 diabetic patients with microalbuminuria. Material and Methods: This Cross sectional study was conducted at Sheikh Zayed Hospital, Rahim Yar Khan from January 2019 to July 2019. Total 135 patients aged 35-80 years with type 2 Diabetes Mellitus and having microalbuminuria were enrolled. Their demographic information was noted. Then patients underwent an exercise treadmill test. Silent myocardial ischemia was diagnosed if the test was positive for ischemia in the absence of anginal symptoms. Results: Mean age of the patients was 61.10±13.52 years, and there were 69 (51.1%) male patients were. Mean body mass index was 30.09±5.70 kg/m2. Mean duration of disease was 12.59±9.18 years. Overall, SMI was seen in 37(27.4%) patients. Patients in the age group 66-80 had the highest frequency of SMI (81.1%). Patients who had SMI, all of them were obese. P-value= 0.000. Duration of disease was also significantly associated with SMI. Age, Gender and smoking status of patients were not significantly associated with SMI. Conclusion: SMI was seen in 27.4% patients. SMI was significantly associated with age, body mass index and duration of diabetes.

Keywords: Silent Myocardial Ischemia, Type 2 diabetes mellitus, Microalbuminuria.