Abstract
ENHANCEMENT OF OLMESARTAN MEDOXOMIL DISSOLUTION BY SURFACE SOLID DISPERSION

Afaf A. Ramadan, Gamal M. El Maghraby, Zeinab Al Kasaby and Mona Abdelaziz*

ABSTRACT

Olmesartan Medoxomil (OM) is an angiotensin-receptor blocker. Based on the solubility and permeability, (OM) is classified as class II drug according to the biopharmaceutics classification system (BSC), meaning that the drug is poor soluble. This is believed to be responsible for its low bioavailability. Therefore, the objective of this study was to enhance Olmesartan Medoxomil dissolution by surface solid dispersion (solvent evaporation). The drug was precipitated from its ethanolic solution in presence of Aerosil and hydrophilic polymer. The selected polymer was Polyvinyl Pyrrolidone 40T (PVP). Thermal behavior results confirmed reduced drug crystallinity. FTIR spectroscopy indicated drug-excipient compatibility. All formulations showed improvement in drug dissolution compared to pure drug. Surface solid dispersion (solvent evaporation) in presence of hydrophilic polymer is a promising approach for enhancing dissolution rate of poorly soluble drugs.

Keywords: Olmesartan Medoxomil, Polyvinyl Pyrrolidone 40T (PVP), Aerosil 200, enhance dissolution rate.


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