Abstract
ANTIDEPRESSANT-LIKE EFFECTS OF THE HYDROALCOHOLIC EXTRACTS OF LEAVES FROM MORINDA LUCIDA IN MICE

Bakou Niangoran François*, Coulibaly Siendou, Bleu Gomé M., Ba A. and Atayi E.

ABSTRACT

Objective: The aim of the present study is to evaluate the antidepressant-like effect of hydro ethanolic extract of leaves from Morinda lucida in mice. Material and Methods: Mice were randomly divided into five groups (n = 5/group): control group (distilled water), standard group where Amitriptyline (20mg/kg b.w., IP) was used as standard drug and three test groups where three doses of the hydro ethanolic extract of Morinda lucida (100, 200, and 400 mg/kg) was used for two weeks treatment. To assess the antidepressant-like effect of hydro ethanolic extract of leaves from Morinda lucida forced swimming test (FST), tail suspension test (TST) and measurement of locomotor activity test (OFT) have been done in mice. Results: The results showed that a strong and dose-dependent antidepressant effects in different mice models. The main findings of the hydro ethanolic extract of Morinda lucida significantly reduced the duration of immobility times in the forced swimming test (p < 0.001). Likewise, the extract significantly decreased the immobility time in the tail suspension test (p < 0.001). Conclusion: The results of the present work suggest that a hydro alcoholic extract of the hydro ethanolic extract of Morinda lucida leaves may possess an antidepressant effect.

Keywords: Morinda lucida, antidepressant, activity, mice.


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