A REVIEW ARTICLES ON CURCUMIN IS A NOVEL DRUG AND ITS ANTICANCER ACTIVITY
*Kalyani Adhikary and Dr. Bhanu Pratap Sahu
ABSTRACT
Curcumin is a potential drug for various diseases including cancer. Prime limitations associated with curcumin are low water solubility, rapid hydrolytic degradation and poor bioavailability. Numerous studies have demonstrated that curcumin possesses anti-oxidant, anti-inflammatory and anticancerous properties. The purpose of this review is to focus on the anti-tumor effects of curcumin. More recently curcumin has been found to possess anti-cancer activities via its effect on a variety of biological pathways involved in mutagenesis, oncogene expression, cell cycle regulation, apoptosis, tumorigenesis and metastasis. Curcumin has been studied in multiple human carcinomas including melanoma, head and neck, breast, colon, pancreatic, prostate and ovarian cancers. Curcumin has the activity to inhibit cell proliferation, cytochrome P450 isoenzymes. It suppress certain oncogenes. It inhibits cell-cycle-related proteins, tumor implantation. Curcumin has been used extensively in Ayurvedic medicine for centuries, as it is nontoxic and has a variety of therapeutic properties including anti-oxidant, analgesic, anti-inflammatory and antiseptic activity. This novel curcumin has an opportunity to treat cancer with SLN making formulation, nanospheres, liposomes, in a better manner with lower dose by Homogenous SLN which obtain by Homogenization –ultrasonication method. Curcumin is one such potential candidate. The study postulates the drug form has the potential to be used as an anticancer agent in affected human subjects.
Keywords: Curcumin, Anticancer drug, Bioavaiability, Solid lipid nanoparticles, Homogenisation.
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