European Journal of Biomedical and Pharmaceutical Sciences

COLON TARGETED DRUG DELIVERY SYSTEM: A REVIEW ON TREATMENT OF ULCERATIVE COLITIS

Dr. Shubhangi C. Daswadkar* and Sumit Manoj Sonavane

ABSTRACT

Colon specific drug delivery has gained increased importance not just for delivery of the drugs within the treatment associated with the colon, but also as a possible site for the systemic delivery of therapeutic peptides and proteins. To realize successful colon targeted drug delivery, a drug need to be shielded from degradation, release and absorption within the upper portion of the alimentary tract then to be ensured abrupt or controlled release within the proximal colon effects. The review, mainly compares with the first approach for ulcerative colitis such as CDDS namely prodrugs, pH and time dependent systems, and microbially triggered systems, which achieved limited success and osmotic controlled drug delivery which are unique in terms of achieving in vivo site specificity, and feasibility of producing process. May be a chronic mucosal inflammatory condition which will affect any parts of the colon, and is characterised by periods of remission and active disease related to symptoms of abdominal pain, diarrhea, rectal bleeding and fecal urgency.

Keywords: To realize successful colon targeted drug delivery, a drug need to be shielded from degradation, release and absorption within the upper portion of the alimentary tract then to be ensured abrupt or controlled release within the proximal colon effects.