EFFECTS OF ANTIDIARRHEAL AND THROMBOLYTIC ACTIVITIES OF METHANOL EXTRACT OF CINNAMOMUM CECIDODAPHNE MEISSN. BARKS
Mohammed Aktar Sayeed* Mohammad Fazlul Kabir , Rashedul Alam2, Rana Dhar , Limon Kanti Shill, Naymul Karim, and Ahsan Ullah
ABSTRACT
Objective: To investigate the Effects of Antidiarrheal and
Thrombolytic Activities of methanol extract of Cinnamomum
cecidodaphne Meissn. Barks. Castor oil induced diarrhoea test were
used to examine the in-vivo antidiarrheal activity in Swiss albino mice.
Results: In vitro clot lysis model was undertaken to investigate the
thrombolytic action of the extract. Data were analysed by using
statistical software statistical package for social science (SPSS, version
19.0). In this study of antidiarrhel activity Loperamide was used as a
standard. For thrombolytic test Streptokinase used as positive control.
In case of antidiarrheal study value was found 76.36% 400mg/kg
where standard was found 83.33% and the extract shown 35.08% of thrombolysis effect
where streptokinase was found 77.06% of clot lysis effect. Conclusion: The extract showed
significant activity as compare to standard drugs. Methanol extract of C. cecidodaphne
Meissn barks might be triggering the premonition of novel drug discovery in future due to its
antidiarrheal effect in animal model.
Keywords: Antidiarrheal activity, Castor oil, Cinnamomum cecidodaphne Meissn. Thrombolytic activity, % lysis of clot.
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