NANOGELS: AN OVERVIEW OF PROPERTIES, PHARMACEUTICAL APPLICATIONS AND DRUG LOADING TECHNIQUE
Dr. Ashish Prakash Gorle* and Tejaswini Dipak Tatar
ABSTRACT
A nanoparticle which is composed of a hydrogel with a cross linked hydrophilic polymer network is known as “Nanogel”. The term nanogels defined as the nanosized particles formed by physically or chemically cross-linked polymer networks that is swell in a good solvent. The term “Nanogel” was first introduced to define cross-linked bifunctional networks of a polyion and a nonionic polymer for delivery of polynucleotides (cross-linked polyethyleneimine (PEI) and poly (ethylene glycol) (PEG) or PEG-cl-PEI). Nanogels based materials have high drug loading capacity, biocompatibility, and biodegradability which are the key points to design a drug delivery system effectively. Sudden outbreak in the field of nanotechnology have introduced the need for developing nanogel systems which proven their potential to deliver drugs in controlled, sustained and targetable manner. With the emerging field of polymer sciences it has now become inevitable to prepare smart nano-systems which can prove effective for treatment as well as clinical trials progress. The brief review aims at providing comprehensive illustrations on the novel applications, drug loading technique, mechanism of drug release from nanogels. Further, current status, clinical trial status, and future perspective of nanogels have been summarized.
Keywords: Nanoparticle, Nanogel, Nanotechnology, polymer.
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