European Journal of Biomedical and Pharmaceutical Sciences

BRAIN TARGETING NASAL DRUG DELIVERY SYSTEM

Dr. Shubhangi Daswadkar*, Mohini B. Thorat

ABSTRACT

Present review highlights the nasal mucosa as an administration route for targeting the central nervous system, in specific, the brain. Thus, since last few decades, nasal route has attracted a broad observation of researcher, as a convenient, non- invasive, reliable and safe pathway to reached faster and higher levels of drug in the brain. The nasal mucosa when differentiate to other mucous membrane is easily accessible and gives a practice entrance portal for small and large molecule. The brain and central nervous system both have limited availability to blood chamber due to number of barriers. Intranasal drug delivery is one of the attensive delivery options for the brain targeting, as the brain and nose chamber are linked to each other through the olfactory route and through peripheral circulation. This review will discuss factor affecting brain targeted nasal delivery system.

Keywords: Nasal Delivery, Brain Targeting, Blood Brain Barrier, Central Nervous System, Cerebrospinal Fluid (CSF).