Abstract
NOSE TO BRAIN DELIVERY FOR TREATMENT OF NEUROLOGICAL DISORDERS: A POTENTIAL ROUTE FOR BRAIN TARGETING

Meraj Siddiqui Israfil Siddiqui*, Nayan Ashok Mule and Dr. S. D. Pande

ABSTRACT

Delivery of drug to the brain is Major challenge due to Presence of two Physiological barriers that restricts the delivery of drug to the Central Nervous System [CNS], The Blood Brain Barrier [BBB] and Blood Cerebrospinal Fluid Barrier [BCSFB]. The BBB is present in most organisms in which the CNS is well-developed and it protects the brain from the foreign matter and maintains the cerebral homeostasis. The drug has to be delivered to the brain for treating CNS diseases like Alzheimer’s, Meningitis, Schizophrenia, Migraine and Parkinson’s diseases. These nerve pathways initiate in the nasal cavity at olfactory neuroepithelium and terminate in the brain. The drug is administered for the treatment of CNS issues for treating CNS disorders and systemic administration for sedatives, analgesics, corticosteroid hormones, hormones, vaccines and cardiovascular drugs through the nasal mucosa. The BBB, which is present at the capillary level regulates and monitors the entry of all small and large molecules entering into the brain. Excitotoxicity and apoptosis are other reasons for neurodegeneration. Hyperactivity of glutamate receptors leads to deleterious effects on neurons, which can be attributed to the over production of free radicals.

Keywords: Nose to brain delivery, Blood Brain Barrier, Central Nervous System, Blood Cerebrospinal Fluid Barrier, Drug Transport and nasal devices.


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