European Journal of Biomedical and Pharmaceutical Sciences

ROLE OF LIPOSOME IN CANCER THERAPY

Lukman Lawal*, Monika Targhotra, Meenakshi K. Chauhan, P.K. Sahoo and Faiza Himasa Idris

ABSTRACT

The use of liposomes for drug delivery began early in the history of nanocarriers. These are small artificial vesicle colloidal, vesiculer structures composed of one or more lipid bilayers surrounding an equal numbers of aqueous compartments. Liposomes are small artificial vesicles of spherical shape that can be created from natural phospholipids and cholesterol, has both hydrophilic and hydrophobic character. A phospholipids bilayer vesicular system is being used for drug delivery application in cancer therapy. The reasons behind the advantages that liposomes offer, improves bioavailability of anticancer drugs and versatility of encapsulating both hydrophilic as well as hydrophobic drugs, liposomes with targeted ligand this can leads to actively targeted site specific therapy of solid tumor. The liposomal formulations for cancer treatments are already in clinics many are in active research. This review explains about the basic liposomes which includes structural‟s, components, method of preparation, mainly focuses on recent advancements of liposomes such as various kind of surface modification currently use liposomes with active or targeted drug delivery along with its advantages and mechanism and their application in the treatments of cancer.

Keywords: Liposomes, structural component of liposome, Targeted drug delivery, Cancer therapy.