CORRELATION OF CYTOLOGY, COLPOSCOPY WITH HISTOPATHOLOGY DURING OPPORTUNISTIC SCREENING FOR CERVICAL PRECANCER LESIONS
Dr. Shazia Anjum, Dr. Vandana Saini* and Dr. Mamta Gupta
ABSTRACT
Background: Cervical cancer is second most common cancer in women in India. It is a preventable disease as it has a well-defined long premalignant phase that can be detected by regular screening tests and follow up. Aim and Objective: The aim of this study was to compare detection of the premalignant lesions of cervix by Pap smear, colposcopy and cervical biopsy in women with gynecological complaints. Materials and Methods: This cross-sectional study was conducted on 100 women who attended Gynaecology OPD with gynecological complaints in June 2018. In the Department of Obstetrics and Gynae at Hindu Rao, Hospital and associated NDMC Medical College, Delhi. All women had Pap smear test by conventional method and colposcopy done at their 1st visit. Women with abnormal colposcopy findings were subjected to cervical biopsy. The results of Pap smear and colposcopy were analyzed and correlated with cervical biopsy. Results: The sensitivity of Pap smear was 45.00%, specificity 60.00%, positive predictive value 69.23%, negative predictive value 35.29% and an accuracy rate of 50.00% for detecting pre-malignant and malignant lesions of cervix. Colposcopy had much higher sensitivity (100%), positive predictive value 74.07%, with accuracy of 76.67% and negative predictive value 100% but had a lower specificity of 30.00%. Conclusion: Pap smear had poor sensitivity compared to colposcopy. Colposcopy had high sensitivity and higher accuracy though the specificity rate was less compared to Pap smear test. Hence, it is suggested that both the tests should be utilized for screening of premalignant lesions of cervix.
Keywords: Pap smear, colposcopy, histopathology, colposcopically directed biopsy, Lugols Iodine.
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