Abstract
IN VITRO STUDY ON ALPHA AMYLASE INHIBITORY ACTIVITY OF ABUTILON INDICUM: EFFECT OF EXTRACTION SOLVENTS

Tanaya Ghosh and Prasanta Kumar Mitra*

ABSTRACT

Abutilon indicum Linn. (A. indicum L.), a medicinal plant, is used in traditional medicine for treatment of toothache, catarrhal bilious, bronchitis, diarrhoea, gonorrhoea and inflammation of bladder as well as in fever. The plant has wide pharmacological activities too. The plant also possesses alpha amylase inhibitory activity. Aim of the present work was to see effect of solvent extracts on in vitro alpha amylase inhibitory activity of A. indicum L. leaves. A. indicum L. leaves were collected from medicinal plant garden of North Bengal University and identified by the taxonomist. Solvent extractions of the leaves were made separately by using chloroform, petroleum ether, ethanol, isopropanol and hexane. Extracts were separately dried and processed for in vitro alpha amylase inhibitory activity by standard method. Acarbose, an alpha amylase inhibitor, was used as control. Results showed that ethanol extract of A. indicum L. leaves had maximum alpha amylase inhibitory activity in comparison to that of other solvent extracts. This study therefore indicates that ethanol extract of A. indicum L. leaves may be used in the management of diabetes.

Keywords: Abutilon indicum linn. leaves; solvent extractions; alpha amylase inhibitory activity, acarbose, diabetes.


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