European Journal of Biomedical and Pharmaceutical Sciences

ASSOCIATION OF VITAMIN D DEFICIENCY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ITS SEVERITY

Hitesh Panchal, Aakriti, Yash Ashara, Neel Mittal, Abhishek Vadher* and Rono Korra

ABSTRACT

Background: Vitamin D deficiency is wide spread in India. Vitamin D has role in immunity and is capable of decreasing pulmonary inflammatory response. Thus Vitamin D also has a role in Chronic Obstructive Pulmonary disease. Many studies have shown that Vitamin D deficiency in COPD is associated with increased severity and low FEV1. In this study, we tried to find a co-relation between Vitamin D deficiency and COPD severity. Methods: This is a cross-sectional performed over a period of 1 year. 230 COPD patients in the out-patient department were included in the study. Patients with other co-morbidities like hypertension, diabetes mellitus, chronic kidney disease, liver disease etc. were excluded from the study. Serum Vitamin D levels were measured in all the patients. Spirometry and Pulmonary Function Tests were conducted in all the patients. Results: Among 230 patients, 202 patients were males and 18 patients were females. All patients were aged between 40 and 70 years. Mean BMI of the study population was 27.40 ±4.91 kg/m2. The study population was distributed in 4 groups based on the GOLD criteria. 30.43% patients were in GOLD criteria 1. 39.56% patients were in GOLD criteria 2. 20.86% patients were in GOLD criteria 3. 9.13% patients were in GOLD criteria 4. Conclusion: In this study, we concluded that Vitamin D deficiency is present in COPD patients. There is a positive co-relation between serum Vitamin D levels and level of severity of COPD.

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