Abstract
SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL PYRAZOLE DERIVATIVES

Pagidirai Sanjeeva*, Yeragodala Narendra Reddy, Kummara Srinivasulu and Prof. Peddakotla Venkata Ramana

ABSTRACT

Novel 1,5-disubstituted pyrazole and isoxazole derivatives like, aryl 5-(3-(trifluoromethyl)phenyl)-1-(substituted phenyl)-1H-pyrazole-3-carboxylic acid have been synthesized and characterized using IR, 1H NMR, 13C NMR and Mass spectral analysis. All the synthesized compounds have been screened for their antibacterial activity against S. aureus, E. coli, B. subtilis, P. aeruginosa, S. pyogenes, K. terrigena and K. pneumoniae and antifungal activity against T. viride, A. flavus, A. brasillansis, and C. albicans. Fungal strains such as T. viride, A. flavus, A. brasillansis, C. albicans by using minimum inhibitory concentration. Interestingly all the synthesized compounds exhibit good antibacterial and antifungal activity.

Keywords: Pyrazole, antibacterial, antifungal.


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