Abstract
STRESS DEGRADATION STUDY OF PACLITAXEL IN BULK BY UV SPECTROSCOPIC METHOD

Namita Tehare* and Madhuri game

ABSTRACT

A simple, sensitive, precise, accurate, economic and rapid UV spectroscopic method has been developed for estimation of paclitaxel. Paclitaxel was a subjected to different stress condition as per ICH guideline Q1A (R2). A stability- indicating UV Spectroscopic method has been developed for analysis of the drug in the presence of the degradation products. Detection carry out at wavelength 223 nm. Degradation of paclitaxel was studied in acid, alkaline, hydrogen peroxide, photolytic and thermal conditions. The amount of degraded drug was calculated by taking absorbance at 223 nm. The drug was found to be more liable to decompositions in acidic, oxidative medium than in alkaline conditions.

Keywords: Paclitaxel, UV- Spectroscopy, API, International Conference on Harmonization.


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