Abstract
FORMULATION AND EVALUATION OF METFORMIN FAST DISSOLVING FILM BY SOLVENT CASTING METHOD

Pingale Rutuja S.*, Surawase Rajendra K., Rane Parag K., Dawange Bhushan S.

ABSTRACT

Metformin is indicated as an adjunct to diet and exercise to increase glycaemic control in adults and paediatric patients 10 years of age and older diagnosed with type 2 diabetes mellitus (DM). The present study is deal with formulation, optimization and evaluation of Metformin mouth dissolving films. Type 2 diabetes mellitus is the condition where instance effect of drug is required. Metformin is one of the most popular drug which used in the treatment of DM. The mouth dissolving films was prepared by using solvent casting method. The concentration of citric acid, sucrose, glycerin and Sodium starch glycolate were kept constant in all formulations (F1-F9) and varying concentration of hydroxy propyl methyl cellulose (HPMC-E15) and methyl cellulose. All the formulations were evaluated for appearance, shape, thickness, weight uniformity, folding endurance, percent elongation, tensile strength, drug content, disintegration time, in-vitro dissolution studies. The formulation ‘F3’ was found to be optimized formulation. It shows results for all evaluation parameters such as weight variation 68.2 mg, folding endurance 13, drug content 99.87%, percent elongation 11, disintegration time 20 sec, and in-vitro dissolution study 82 % at the end of 5 min.

Keywords: Fast dissolving film, Metformin, HPMC-E15, Methyl cellulose, Diabetes mellitus.


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