European Journal of Biomedical and Pharmaceutical Sciences

ORALLY DISINTEGRATING TABLET

Darya Lotfollahiab* and Metin Çelika

ABSTRACT

Orally disintegrating tablets (ODT) have emerged as one of the popular and widely accepted dosage forms especially for pediatric and geriatric patient. ODT have gained considerable attention as preferred alternative to conventional tablet and capsule formulation. Various scientific technique including freeze drying, molding, spray drying, direct compression, etc. have been employed for the development of ODT. These techniques render the disintegration of tablet rapidly and dissolve in a mouth without chewing or additional water intake. The purpose of this study is focused on freeze drying method and compression ascorbic acid and lyophilized ascorbic acid as a API and various form of mannitol (powder, granule, spray dry, lyophilize) as a sweetener to mas unpleasant mouth feel to achieve better taste. The result showed that have given different influence on evaluation taste. The spray dried mannitol provides good flowability but lyophilized offers low flowability. The lyophilized method has decreased dissolution and disintegration time, but the taste has not affected by lyophilized method. Finally, mannitol cannot prevent uninteresting taste of the tablet.

Keywords: Orally disintegrating tablet, flowability, disintegrating, freeze drying, mannitol, leophilized method.