Abstract
SOLUBILITY ENHANCEMENT TECHNIQUES FOR POORLY WATER-SOLUBLE DRUGS: A REVIEW

Rajendra K. Surawase*, Kamalkishor G. Baheti and Avish D. Maru

ABSTRACT

One of the important parameters to achieve desired concentration of drug in blood is drug solubility. A success of formulation development is depending on how effectively it makes drug available for absorption. Among all newly and existing drug candidate about 40 % drugs are lipophilic in nature and fails to reach therapeutic range due to poor aqueous solubility and ultimately it shows slow dissolution and low bioavailability. Selection of solubility enhancement technique depends on drug properties, site of absorption and required dosage form characteristics. This review article covers the area of different conventional and novel approaches of solubility enhancement for poorly water-soluble drugs.

Keywords: Drug solubility, Solubility enhancement, Solid dispersion, Fluidized bed processing.


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