Abstract
A SYSTEMATIC REVIEW: APPLICATION OF METAL COMPLEXES IN MEDICINAL COMPOUNDS

Shweta Jaiswal*, Parimal Katolkar and Jagdish Baheti

ABSTRACT

Transition metal complexes have been of much interest over the last years, largely because of its various applications in biological processes and potential applications in designing new therapeutic agent. The metal complexes offer a great diversity in their action such as; anti-inflammatory, anti-tubercular, anti-infective and anti-diabetic compounds. The aim of this review is a detailed analysis of the usefulness of the metal complexes of some medicinal compounds over the parent ligand. The synthesis and alteration in the pharmacological and/or pharmacotechnical properties of coordination complexes of many pharmaceutical substances like glimepiride, ciprofloxacin, amoxicillin, ampicillin, lansoperazole, isoniazide, naproxen and mixed complexes with transition metals and rare earth metal were studied in this review. The activity of the complexes was usually found to be increased in comparison to parent drug. The influence of certain metals on the biological activity of these compounds has prompted a considerable increase in the study of their coordinatioin behaviour. This review illustrates the role of metals, progresses in synthesis of metal based drugs and their application.

Keywords: Metal complexes, better efficacy, improved activity, synthesis, applications.


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