Abstract
NIGELLA SATIVAM: THYMOQUINON AN OPTIMISTIC OVER PANDEMIC

Aswathi M.C., Fathimath Dilsha*, Chandini S., Akshaya N.P. and Haneen

ABSTRACT

The COVID-19 has been declared a pandemic while there is no specific medicine against its causative agent SARS-CoV-2.As a prophetic medicine Nigella sativa (black seed)which has far reaching possibilities can be used.These plants are tolerant annuals, growing in height from 8-24 inches and contains thymoqunin (TQ) one of the most important bioactive compound .Nigella sativam comprises fixed oils, volatile oils, proteins, saponin and essential oils. It has been reported that human-to-human transmissions of SARS-CoV occurs by the binding between the receptor-binding domain of virus spikes and angiotensin- converting enzyme 2 (ACE2) receptor. TQ intercepts the complex formation at ACE2 sites thus deter endocytosis during replication.TQ also helps in the significant reduction of systolic(SBP) and diastolic blood pressure (DBP) along with reduction in total cholesterol imprint its part in CVD.Anti histaminic and anti inflammatory property of TQ are also reported.This review paper describes how N.sativa could be useful as a compliment to covid-19 treatment.

Keywords: COVID-19, SARS-CoV-2,Thimoqunin,Nigella sativam.


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