Abstract
FORMULATION AND EVALUATION OF FAST DISSOLVING BUCCUAL FILM OF SUMATRIPTANT SUCCINATE

Harsha B. Sakharkar*, Monika Jadhao, Dr. M. D. Game and S. G. Jawaekar

ABSTRACT

Current research is focused on formulation and evaluation of fast dissolving buccal film of sumatriptant succinate used for treatment of migraine. The design of developing drug delivery system is to provide patient with more convenient means of drug administration and maximum drug dissolution in oral cavity to by passing the first metabolism, to increase the convention. The delivery system consist of the oral film, which is simply placed on the patient tongue and any oral mucousal tissue (buccal / sublingual). The film following polymer HPMC E15 used of film forming. The film evaluated for disintregration, dissolution, tensile streght, thickness, folding endurance and elastic modules. Following single subcutaneous or oral dosage of drug in healthy individuals, the terminal estimation half-life of drug is 1.5-2.6 hours.

Keywords: Fast dissolving buccal film sumatriptant succinate, HPMC E15,propylen glycol, methanol, bioavaibility enhancement.


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