ANTI- ARTHRITIC ACTIVITY PROFILE OF VATAGHNI (JUSTICIA GENDARUSSA BURM F.) ON WISTAR ALBINO RATS
Thakur Bhawana, Mallya Suma V.*, Rao Chiatra Bhat Sudhakara and Shetty Nivedita
ABSTRACT
About: Vataghni(Justicia gendurussa Burm. F.) a perennial shrub the leaves of which are used by folklore practitioners in the treatment of arthritis through various dosage forms. Though many drugs are used in arthritis the whole world is looking for safe herbal drug. Materials and method: Leaves of test drug collected and decoction prepared. Anti-arthritic experimental activity evaluated using Freund’s adjuvant induced arthritis model in Wistar albino rats. The rats were selected randomly and grouped into 4 group of 6 rats each. The first group was vehicle control whereas, second group with ibuprofen 100mg/kg. The third group was administered with Friend’s Adjuvant + along with VPK orally, whereas fourth group administered with Friend’s Adjuvant, VPK Dhara(pouring over joint region) externally. The reduction of inflammation was measured on 24hour, 48hour, 72hour, 5th day, 21st day, 30th day respectively and the results were compared with that of the standard drug induced. After 30 days all rats were sacrificed. Histopathological observations of right and left synovial joint recorded. Results: The result strongly support anti-arthritic potential of leaf of Vataghni(Justicia gendarussa Burm F.) and its traditional use in medicine. Test drug Kasaya Pana is more effective as compared to Patra Kasaya dhara. Conclusion: The leaf of Vataghni (Justicia gendurussa Burm F.) is found to be safe and effective in management of arthritis.
Keywords: Vataghni(Justicia gendurussa Burm. F.), Anti-arthritic, Freund’s adjuvant)
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