Abstract
FORMULATION AND EVALUATION OF FEXOFENADINE IMMEDIATE RELEASE TABLETS

Addanki Anusha*, CH. Keerthana, A. Haasini, M. Archana and Mehul Jain

ABSTRACT

This work, deals with formulation and evaluation of Fexofenadine immediate release tablets. Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. Tablets were prepared by wet granulation method; the powder blends were initially evaluated for various pre-compression parameters and later evaluated for post-compression parameters like weight variation, thickness, hardness, drug-content and in vitro drug release. All the results were found to be within the acceptable limits. A constant weight of 30mg Fexofenadine was fixed for all the formulations F1-F10 a As the amount of disintegrant i.e., pre gelatinized starch, CCS was increased for F6 and F8 formulations the cumulative % drug release of these two batches was found to be greater than 95% at 20mins time interval. The effect of disintegrant used in the formulations is seen clearly. The dissolution data was subjected to regression analysis and were fitted to kinetic models, viz., Zero order and First order. It was following First order (R2=0.835). It describes the systems where the drug release rate depends on its concentration. The release kinetics follows first order and Higuchi’s model of kinetics with an R2 of 0.9626, 0.8896 respectively.

Keywords: Fexofenadine, Immediate release, In-vitro, pre gelatinized starch, Kinetics.


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