Abstract
SOLUBILITY ENHANCEMENT OF ETODOLAC USING HOT MELT EXTRUSION

Vaibhav Gulabrao Bhamare*, Ravindra Keshavrao Kamble

ABSTRACT

Aqueous solubility of drug has moreover impact on oral bioavailability of that drug. The aim of present work is to enhance solubility of poor water soluble drug through Hot Melt Extrusion technology. The shear and heat so generated in the process are the crucial factor to govern so as to avoid thermal degradation of drug. Etodolac is a poor water soluble nonsteroidal anti-inflammatory agent selected for the study along with Parteck® MXP and Parteck® SI 150 as a polymer. Varying drug: polymer concentration ratio is then processed using twin screw extruders with keen focus on ideal processing parameters. The extrudates were characterized with thermal, microscopic, and spectroscopic analytical methods. The amorphous form of a drug so produced is comparatively more soluble than the crystalline form.

Keywords: Etodolac, Solubility, Hot melt extrusion, Extruder, Extrudate.


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