European Journal of Biomedical and Pharmaceutical Sciences

CARDIOPROTECTIVE STUDY OF AMINOACIDS - L-ARGININE AND L-LYSINE ON ISOPROTERENOL INDUCED MYOCARDIAL STRESS IN RATS

G. Rani* and K. Ramesh

ABSTRACT

Heart is the vital organ responsible for the purification of blood and it transports to all organs through the circulatory system. Toxic effects of drugs on the heart may mimic almost all the qualities of the heart diseases. Cardiotoxicity or myocardial infarction was induced for the experimental findings in rats by the administration of Isoproterenol. The serum enzymes such as CPK, LDH and SGOT and the serum cholesterol were elevated and they were brought back to near normal levels by the pre-treatment of Arginine and Lysine, which acts as a putative coronary vasodilator and possess negative inotropic and chronoscopic effects. L-Arginine and L-Lysine antagonize the effect of calcium and alters the important cellular processes. Due to its potent vasodilator property, L-Arginine and L-Lysine are known to prevent and relive coronary artery spasms associated with acute myocardial infarction. The present study showed the effect of L-Arginine and L-Lysine on isoproterenol induced myocardial infarction in rats significantly.

Keywords: Cardioprotective activity, amino acids, Arginine, Isoproterenol,