European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF DRUG-DRUG INTERACTION IN CHRONIC DISEASE PATIENTS IN A TERTIARY CARE HOSPITAL

Nayana P. Kunderi, *Jeevals Wilson, Febin Geo Raju, Hadiseh Rezaei and Dr. Beulah Milton

ABSTRACT

Objectives: To assess the Drug-Drug interaction in a chronic disease condition in a tertiary care hospital. Methods: A hospital based Prospective Observational study was conducted for a period of 6 months, to assess the Drug-Drug interaction in a chronic disease condition in a tertiary care hospital. To study the effects and the type of drug interaction using www.drugs.com website. Results: A total of 110 patients were enrolled out of whom, 43 patients were female (39.1%) and 67 were male (60.9%), where 416 DDIs identified, 38 were major (9.13%), 321 were moderate (77.16%) and 57 (13.71%) were minor interactions. The number of potential DDI ranged from 1 to 16; 14 cases (12.7%) showed one potential DDI and 1 case (0.9%) showed 16 potential DDIs. The pharmacokinetic outcome was identified in 119 DDIs (27.05%) (Figure:5) and pharmacodynamics outcome was identified in 297 DDIs. Causality assessment was carried out using Drug Interaction Probability Scale (DIPS) to estimate the probability that an adverse reaction was caused by an interaction of the drugs in question; according to the total score of 10 questions the relationship is Doubtful (<2) (33.5%), Possible (2 to 4) (34.6%), Probable (5 to 8) (21.8%) and Highly probable (≥9) (2.7%). Conclusion: The study helps in understanding the possible drug interaction that can occur in patients with Chronic Obstructive Pulmonary Disease, hypertension, chronic kidney diseases and diabetes mellitus and avoid interactions in the future and provide a better health care to the patients.

Keywords: Drug-drug interactions, pharmacodynamics, pharmacokinetic.