European Journal of Biomedical and Pharmaceutical Sciences

PREVALENCE OF HYPERURICEMIA IN PATIENTS RECEIVED AT THE LABORATORY OF THE NATIONAL REFERENCE UNIVERSITY HOSPITAL CENTER

Nadjioroum Ngam-Asra, Brahim Boy Otchom*, Nguinambaye Mberdoum Memti, Mbaioumanssem Djerané Elie, Abdelsalam Tidjani and Guelmbaye Ndoutamia Anaclet

ABSTRACT

Hyperuricemia is a precipitating factor for gout and kidney disease as well as a significant risk factor for metabolic syndrome and cardiovascular disease. The main causes of increased uricemia are either lower excretion, higher synthesis, or both. The objective of the study is the determination of hyperuricemia in order to improve management of patients received at the National Reference Hospital-University Center (CHU-RN) of N’Djamena in Chad. Material and Methods: this was a prospective, descriptive and analytical study involving 450 patients of both sexes aged 20 to 65 years, received at the laboratory of the CHU-RN for a biochemical assessment in November 2018 to November 2019. Results: The hospital prevalence of hyperuricemia was 35.55%. Men were more represented with 58%. The 20-29 years age group (44%) and normally overweight subjects (51%) were the most represented. Among the 160-hyperuricemia subjects, 10% had gout, 17.5% had arterial hypertension, 16.5% renal failure and 56% asymptomatic. Mean uric acid levels were significantly elevated (p <0.05) in overweight subjects (426.45  189.51μmol / l) in the age group of 46-65 years (431.32  165.43μmol / l) and subjects with renal failure (659.57  217.39μmol / l). Carrier levels of uric acid, triglycerides, total cholesterol and LDL cholesterol increased with age with the exception of HDL cholesterol. Investigation of the independent relationship between uricemia and lipid profile showed a strong correlation between uricemia and triglycerides, total cholesterol, HDL cholesterol and LDL cholesterol at significance level P <0.01. The study on the relationship between uricemia and hyperuricemia-related diseases showed that there is also a correlation between uricemia and arterial hypertension (hypertension), gout and renal failure at the level of significance. P <0.01. Conclusion: The hospital prevalence of hyperuricemia was 35.55%. This is why it is important to undertake a study to assess hyperuricemia in the Chadian population.

Keywords: hyperuricemia, Prevalence, lipid balance, CHU-RN.