European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL EVALUATION AND DOCKING STUDIES OF NOVEL 1, 2, 3 TRIAZOLE HETERO CYCLIC COMPOUNDS CONTAINING DIOXAPHOSPHOLANE DERIVATIVES

*D. Rajesh, G. Govindu, B. Saritha, L. K. Ravindranath

ABSTRACT

Novel derivatives of (Z)-N'-(1-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)(-5-chloro/ bromo)-2-oxoindolin-3- ylidene)-2-(4- methyl/ methoxy/ trifluoro/ nitro) cyclohexa-1,3-dien-1-yloxy)benzo[d] [1,3,2]dioxaphosphole-5- carbohydrazide 2-oxide 9(a-o) as per scheme-1 were Synthesized by condensation reaction of (Z)-N'-(1-((1- benzyl-1H-1, 2, 3-triazol-4-yl) methyl) (5-chloro/bromo)-2-oxoindolin-3-ylidene)-3, 4-dihydroxybenzo hydrazide 7(a-c) and (Phenyl) phosphorodichloridates 8(a-g). The synthon 7(a-c) was obtained by condensation reaction between (Z)-3, 4-dihydroxy-N'-(5- chloro / bromo)2-oxo-1-(prop-2-yn-1-yl) indolin-3-ylidene) benzohydrazide 5(a-c) (azidomethyl) benzene(6) and CUSO4-Cu turnings. The synthon 5(a-c) was obtained by reaction between 3, 4-dihydroxybenzohydrazide (3) with N-Propargyl Isatin. The synthon (3) was obtained by condensation reaction between of ethyl 3,4dihydroxybenzoate and hyrazinehydrate. The structures of newly synthesized compounds were established by IR, 1HNMR, 13C-NMR, 31P-NMR and elemental analysis. The newly synthesized compounds were subjected to various biological activities and docking studies.

Keywords: 1, 2, 3 triazole, Propargyl isatin, (Phenyl) phosphorodichloridates, antimicrobial and Docking studies.