European Journal of Biomedical and Pharmaceutical Sciences

ANTI-NOCICEPTIVE POTENTIAL OF METHANOL EXTRACTS OF CRANIUM JAGUS (J. THOMPS) IN MICE

Wakeel O. K.*, Adebayo-Moggaji R. A., Awosan B. O., Olatoyan-Layonu T. J., Olapade M. K., Kolawole O. T. and Adeyeba A. O.

ABSTRACT

Objective: The study investigated the antinociceptive potential of methanol leaf and bulb extracts of Cranium jagus in mice. Methods: The leaf and bulb extracts of Cranium jagus (CJL and CJB) were prepared as per standard procedures and evaluated at three different doses (200, 400, and 800 mg/kg, i.p), they were screened for anti-nociceptive (hot plate test, acetic acid-induced pain, formalin-induced paw lick). Results: The extract of CJL significantly (p<0.05) increased the latency time against the thermal stimulus-induced by hot-plate, inhibited neurogenic and inflammatory pain induced by formalin. Similarly, CJB produced a significant (p<0.05) reduction in licking time in inflammatory pain, but not in neurogenic pain. Both extracts significantly (p<0.05) inhibited the abdominal constriction due to irritation of the stomach in acetic acid-induced pain, dose-dependently. Conclusion: This study showed that Cranium jagus leaf and bulb extracts possessed analgesic activity. Cranium jagus leaf is centrally and peripherally mediated, while, Cranium jagus bulb is peripherally mediated. Our findings support the acclaimed usefulness of Cranium jagus in folkloric medicine.

Keywords: Cranium jagus, anti-nociceptive, formalin, hot-plate, analgesic.