European Journal of Biomedical and Pharmaceutical Sciences

INTRAHEPATIC CHOLESTASIS OF PREGNANCY & ADVERSE PERINATAL OUTCOMES

Ahmad M. Dweekat, MD*, Ayyed M. Ashamaseen, MD, Anas S. Almasaleha, MD, Ma'an A. Aldradkah, MD, and Omar Z. Obeidat, MD

ABSTRACT

Introduction: Pregnancy can come up with intrahepatic cholestasis in third trimester attributed by any of the several medical conditions that affects liver. Intrahepatic cholestasis is a functional disorder involving hepatic parenchymal cells and intrahepatic bile ducts. It can lead to adverse fetal outcomes in cases of prolonged diagnosis and delayed treatment. Objective: The current study was done to find correlation amongst effects of intrahepatic cholestasis during pregnancy, health of fetus and pregnancy carrier and health of neonates once delivered. Methods: It was performed through quantitative examinations by accumulating data via questionnaires and analyzing it using SPSS statistical software at Royal Medical Services Hospital, Jordan for three years. 100 cholestasis pregnant females out of 12,000 women were diagnosed and studied. Results: Incidence rates of IHC in selected cohort was found to be 0.83% . Study indicated that IHC/obstetric cholestasis is major factor that is governed by type of pregnancy and number of deliveries having a history of liver disease. Studying fetal outcomes did not yield any connection with respective factors that were considered. Distinct processes of analysis did not give any significant results.Conclusion: Future studies are recommended for affirming any correlations for fetal outcome by accounting novel factors as subjects here are variables getting affected with masked factors. It can be concluded from the obtained results that obstetric cholestasis (OC) can be treated or avoided by administering concomitant and related medical conditions.

Keywords: Intrahepatic cholestasis, pregnancy, obstetric cholestasis, fetal outcome.