Abstract
DETERMINATION OF PROTEIN C LEVEL IN PATIENTS WITH NEPHROTIC SYNDROME AT KHARTOUM STATE

Nahala Kamal E. H. Elhag* and Mahdi H. A. Abdalla

ABSTRACT

Background: Nephrotic syndrome has many clinical manifestations including thrombosis and thromboembolic events. The hypercoagulability state in nephrotic syndrome could be related to deficiency of naturally occurring anticoagulant like Antithrombin III (ATIII) protein C and S. Aim: The aim of this study was to determine protein C level among Sudanese patients with nephrotic syndrome. Material and method: A total of 90 samples were included (45) samples as case and (45) samples as control. Protein C level was measured using Sandwich-ELISA. Results: The present study showed that the mean of Protein C level among case group (49.6±15.5), was significantly lower than control group (81.27±15.8), (P-value 0.000), there was no correlation between age and protein C level.

Keywords: Nephrotic Syndrome, Protein C, Sudan.


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