ALZHEIMER AND MODELS - AN AGE BASED REVIEW, DEVELOPMENT OF ALZHEIMER’S AT EARLY AGE AND OLD AGE
Kavitha S. K.*, Shilpashree A. T., Nagaraj N. Durgadasheemi and Deepika Pardhe
ABSTRACT
The most highly destructive brain disorder in elderly people is Alzheimer’s disease and it has become a major public health problem. It is mainly characterized by an aging process, whereas a steadily increasing effort directed at discovering the etiology of the disease and developing pharmacological treatment. By using symptomatic treatment mainly focusing on cholinergic therapy. Alzheimer disease drugs like glutamine, memantine, ambenonium used for treatment of cognitive disturbance. Alzheimer disease includes anti-inflammatory agents, and antioxidants is characteristic needs for further studies. Antidepressant, antipsychotics, mood stabilizers, anxiolytics, & hypnotics these are also used for the treatment of behavioral and cognitive disturbance. In recent clinical diagnostic guidelines, it shows that the improved treatment for both Biochemical & behavioral problems. In the disturbance for cognitive, randomized, double-blind, placebo-controlled, parallel-group these studies are also used for measuring a performance-based test of cognitive function,in the daily activities of living and behavior cholinesterase inhibitors. Alzheimer's disease is one of the most highly destructive brain disorders of elderly humans. It is a preserved,and disease that is instead becoming a major public health problem. The last nonetheless characterized by an ageing processa steadily increasing effort directed at discovering the etiology of the disease and developing pharmacological treatment. Recent developments include improved clinical diagnostic guidelines and improved treatment of both cognitive disturbance and behavioral & Biochemical problems. Symptomatic treatment mainly focusing on cholinergic therapy has been clinically evaluated by randomized, double-blind, placebo-controlled, parallel-group studies measuring performance-based tests of cognitive function, activities of daily living, and behavior Cholinesterase inhibitors, including galantamine memantine, ambenonium are the recommended treatment of cognitive disturbance in patients with Alzheimer's disease. The role of estrogen replacement, anti-inflammatory agents, and antioxidants is controversial and needs further study. Antidepressants, antipsychotics, mood stabilizers, anxiolytics, and hypnotics are used for the treatment of behavioral disturbance Future directions in the research and treatment of patients with Alzheimer's disease include: applying functional brain imaging techniques in early diagnosis and evaluation of treatment efficacy; development of new classes of medications working on different neurotransmitter systems (cholinergic, glutamatergic, etc.), both for the treatment of the cognitive deficit and the treatment of the behavioral disturbances; and developing preventive methods (amyloid p-peptide immunizations and inhibitors of β-secret’s and γ-secretase).
Keywords: Neuropsychology, Cognition, Neuroscience, Mild cognitive impairment, Biomarkers, Clinical trials.
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