European Journal of Biomedical and Pharmaceutical Sciences

A OVERVIEW OF NASAL TO BRAIN DRUG DELIVERY

Daniyal Abdullah*, Suchita Onkar Kunjam, Mohit Raut, N. N. Bobade and K. K. Tapar

ABSTRACT

Use of the nasal route for the delivery of challenging drugs such as small polar molecules, vaccines, hormones, peptides and proteins has created much interest in nowadays. Due to the high permeability, high vasculature, low benzymatic environment of nasal cavity and avoidance of hepatic first pass metabolism are well suitable for systemic delivery of drug molecule via nose. The unique relationship between nasal cavity and cranial cavity tissues in anatomy and physiology makes intranasal delivery to the brain feasible. An intranasal delivery provides some drugs with short channels to bypass the blood–brain barrier (BBB), especially for those with fairly low brain concentrations after a routine delivery, thus greatly enhancing the therapeutic effect on brain diseases. In the past two decades, a good number of encouraging outcomes have been reported in the treatment of diseases of the brain or central nervous system (CNS) through nasal the paper also includes. The different types of batters which affects the delivery and how to overcome it low bioavailability low membrane transport enzyme degradation etc physicochemical propertiesthats overcome by prodrug inoveative formulation absorption enhancer etc drug are delivered through the verious type of divices to nose to reach brain.

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