Abstract
COMPARATIVE HISTOPATHOLOGICAL EFFECTS OF METFORMIN AND GLIBENCLAMIDE ON LIVER, KIDNEY & PANCREAS IN ALLOXAN INDUCED DIABETIC ALBINO RATS

*Dr. Nuzhat Bashir, Dr. Sunanda Raina

ABSTRACT

Introduction: Diabetes mellitus is a systemic metabolic disorder characterised by elevated blood glucose levels due to absolute or relative deficiency of insulin secretion from pancreatic β-cells. Diabetes is responsible for causing impairment in functions of liver, kidney & pancreas. Oral hypoglycemic drugs like metformin and glibenclamide improved functions of liver, kidney &pancreas. Hence in this study we evaluated the comparative histopathological effect of metformin and glibenclamide on liver, kidney & pancreas in Alloxan induced diabetic rats. Material and Methods: The present study was conducted on 24 experimental animals which were divided into four groups of 6 rats in each group and were treated accordingly Group 1:Healthy control (HC) rats, Group 2: Diabetic control (DC) rats,Group 3: Diabetes mellitus (DM) + Metformin(M) rats, Group 4: Diabetes mellitus (DM) + Glibenclamide(G) rats.After 28 days of treatment rats were sacrificed and blood glucose and body weight was determined along with histopathological study of liver, kidney & pancreas. Result: The results showed that both Metformin and Glibenclamide reversed Alloxan induced diabetic histopathological changes in liver, kidney & pancreas in Albino rats. Conclusion: The present Results demonstrate that normoglycemia with metformin and glibenclamide ameliorates diabetic induced histopathological lesions in liver, kidney & pancreas.

Keywords: Diabetes, Histopathology, Liver, Kidney, Pancreas, Metformin, Glibenclamide.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW OCTOBER ISSUE PUBLISHED

    OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT