European Journal of Biomedical and Pharmaceutical Sciences

COMPARATIVE HISTOPATHOLOGICAL EFFECTS OF METFORMIN AND GLIBENCLAMIDE ON LIVER, KIDNEY & PANCREAS IN ALLOXAN INDUCED DIABETIC ALBINO RATS

*Dr. Nuzhat Bashir, Dr. Sunanda Raina

ABSTRACT

Introduction: Diabetes mellitus is a systemic metabolic disorder characterised by elevated blood glucose levels due to absolute or relative deficiency of insulin secretion from pancreatic β-cells. Diabetes is responsible for causing impairment in functions of liver, kidney & pancreas. Oral hypoglycemic drugs like metformin and glibenclamide improved functions of liver, kidney &pancreas. Hence in this study we evaluated the comparative histopathological effect of metformin and glibenclamide on liver, kidney & pancreas in Alloxan induced diabetic rats. Material and Methods: The present study was conducted on 24 experimental animals which were divided into four groups of 6 rats in each group and were treated accordingly Group 1:Healthy control (HC) rats, Group 2: Diabetic control (DC) rats,Group 3: Diabetes mellitus (DM) + Metformin(M) rats, Group 4: Diabetes mellitus (DM) + Glibenclamide(G) rats.After 28 days of treatment rats were sacrificed and blood glucose and body weight was determined along with histopathological study of liver, kidney & pancreas. Result: The results showed that both Metformin and Glibenclamide reversed Alloxan induced diabetic histopathological changes in liver, kidney & pancreas in Albino rats. Conclusion: The present Results demonstrate that normoglycemia with metformin and glibenclamide ameliorates diabetic induced histopathological lesions in liver, kidney & pancreas.

Keywords: Diabetes, Histopathology, Liver, Kidney, Pancreas, Metformin, Glibenclamide.