European Journal of Biomedical and Pharmaceutical Sciences

ASPECTS OF NITRIC OXIDE SYNTHASE IN PLATELETS OF KAPOSI’S SARCOMA

Mugdha Nandedkar*, Shreyal Darole, Pritam Waghmode, Neha Agarwal, Rajesh Oswal

ABSTRACT

Nitric oxide synthases are a family of enzymes catalyzing the production of nitric oxide from L-arginine. Nitric oxide (NO) is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. The enzyme nitric oxide synthase (NOS) of which there are three isoforms. Neuronal (nNOS, NOS1) and endothelial (eNOS, NOS3) are constitutive calcium-dependent forms of the enzyme that regulate neural and vascular function respectively. The third isoform (iNOS, NOS2), is calcium-independent and is inducible. Importantly, various studies have shown that all three isoforms of NOS, (iNOS, eNOS and nNOS), have been detected in tumour cells from a wide range of isolates. NOS activity has been observed in human tumour cell lines and cells from tumour biopsies. However, the precise function(s) of NO in tumour biology remains unclear, and several lines of research have indicated that NO may have dual effects in cancer. The various aspects of nitric oxide syanthase in different types of Kaposi’s sarcoma are summarized under this review as well as some general immune response of NO.

Keywords: Nitric oxide, nitric oxide syanthase, kaposis sarcoma, iNOS.