European Journal of Biomedical and Pharmaceutical Sciences

ADVANCEMENT IN IMMEDIATE RELEASE TABLETING: A REVIEW

Yuveraj Singh Tanwar, Kamal Singh Rathore and Kuldeep Singh*

ABSTRACT

Tablet is the utmost popular among all dosage forms existing today because of its convenience of self-administration, compactness and easy manufacturing; however, in many cases immediate onset of action is required than conventional therapy.To overcome these drawbacks, immediate release pharmaceutical dosage form has emerged as alternate oral dosage forms. There are novel types of dosage forms that act very rapidly after administration. The basic approach used in development tablets is the use of super-disintegrants likeCroscarmellose, Primogel, Kollidon CL etc. which provide immediate disintegration of tablet after administration. The current development in immediate release tablets such as Novel granulation technologies, electrostatic dry powder coating process, Novel Hole Technology in Fast Dissolving Tablets, Hot-Melt Extrusion and Injection Molding also provides an opportunity for a line extension in the market place.

Keywords: Immediate Release formulation; Super-Disintegrant; Granulation; Compression.