Abstract
FORMULATION AND EVALUATION OF GASTRO-RETENTIVE FLOATING TABLETS OF RISEDRONATE SODIUM

Arpana*, Dr. Prashanta Bose, Anju, Prachi Sharma, Ajeet Pal Singh and Amar Pal Singh

ABSTRACT

Aim: The present study is planned with the brief objectives to preparation of gastro-retentive floating tablets of Risedronate Sodium by direct compression method polymers or combination of these. Material & Methods: In methodology, gastro-retentive floating tablets of Risedronate Sodium by direct compression method polymers or combination of these were made. The evaluation of gastro retentive formulation was done by the many parameters i.e. angle of repose, bulk density, porosity, weight variation, hardness, friability, swelling index, water uptake etc. Result: Compression force was adjusted to obtain tablets of hardness 6-9 kg/cm2 with 4.0 mm tablet thickness. All formulation from A1 to A7 was evaluated with thickness and diameter of tablets measured by vernier caliper. Thickness and diameter was in range of 3.99 ±0.02 to 4.24±0.07& 12.06 ±0.04 to 12.16±0.05 respectively. The hardness was in range of 7.4±0.03 to 9.0±0.06kg/cm2, which was measured on Monsanto hardness tester. Drug content release was in the range of 98.33±0.12 to 108.96±0.16 shown in Table (no. 3). The percentage drug release was found 58% after 7 hrs. for all the formulations A1-A7. Results of Water uptake study showed that the order of swelling in these polymers could indicate the rates at which the preparations are able to absorb water and swell. Maximum liquid uptake and swelling of polymer was achieved up to 10 hrs and then gradually decreased due to erosion. Conclusion: In the present era, gastro retentive dosage forms (GRDF) receive great attention because they can improve the performance of controlled release systems. This retains in the stomach for a sufficient time interval against all the physiological barriers, releases active moiety in a controlled manner, and finally is easily metabolized in the body.

Keywords: Osteoporosis, Chronic pain, Peak bone mass, Gastro-Retentive Floating, Risedronate Sodium.


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