Abstract
FORMULATION AND EVALUATION OF MOUTH DISSOLVING FILM OF CHLORPHENIRAMINE MALEATE

Poornima Sirohi, Navneet Verma and Vijay Sharma*

ABSTRACT

Aim of present study was to develop mouth dissolving filmt that disintegrates rapidly in mouth by using tasteless drug resin complex (DRC) of Chlorpheniramine maleate (CPM) using Tulsion-335 as ion exchange resin. Formulated drug resin complex was evaluated for by taste and percentage drug loading. Formulated DRC was characterized by infrared spectroscopy. Different batches were developed using optimized DRC by solvent casting method. In vitro release of CPM from formulation in simulated salivary fluid was more than 95% within 2 minutes. Taste masking and in vivo disintegration were in acceptable range. Among different batches F1 batch was found suitable with drug-resin complex to get the low disintegration time along with good physicomechanical properties. These results indicated that the disintegration and drug release of CPM can be increased to a greater extent by optimizing various formulation variables in formulation.

Keywords: Chlorpheniramine maleate, Tulsion 335, Kyron T 314, Poly ethylene glycol.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW OCTOBER ISSUE PUBLISHED

    OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT