Abstract
FORMULATION AND EVALUATION OF MOUTH DISSOLVING FILM OF CHLORPHENIRAMINE MALEATE

Poornima Sirohi, Navneet Verma and Vijay Sharma*

ABSTRACT

Aim of present study was to develop mouth dissolving filmt that disintegrates rapidly in mouth by using tasteless drug resin complex (DRC) of Chlorpheniramine maleate (CPM) using Tulsion-335 as ion exchange resin. Formulated drug resin complex was evaluated for by taste and percentage drug loading. Formulated DRC was characterized by infrared spectroscopy. Different batches were developed using optimized DRC by solvent casting method. In vitro release of CPM from formulation in simulated salivary fluid was more than 95% within 2 minutes. Taste masking and in vivo disintegration were in acceptable range. Among different batches F1 batch was found suitable with drug-resin complex to get the low disintegration time along with good physicomechanical properties. These results indicated that the disintegration and drug release of CPM can be increased to a greater extent by optimizing various formulation variables in formulation.

Keywords: Chlorpheniramine maleate, Tulsion 335, Kyron T 314, Poly ethylene glycol.


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