Abstract
FORMULATION AND EVALUATION OF FLUCONAZOLE BUCCAL TABLETS CONTAINING MICROPARTICULATE SYSTEM FOR CONTROLLED RELEASE

*Nagendra R., Charan C. S. and Hanumanhachar Joshi

ABSTRACT

The present study aimed at formulation and Evaluation of buccal tablets containing microparticulate system for controlled release of Fluconazole using blend of polymers in the treatment of candidiasis. The microparticles of Fluconazole were prepared by spray drying technique. The prepared microparticles were compressed into buccal tablets and evaluated for mucoadhesive properties, swelling index, invitro drug release studies. It was found that the Fluconazole release rate increased with a decreased amount of polymers. This can be adjusted by maintaining the concentration of the polymers. The formulation FC2 was found to be optimum formulation.

Keywords: Fluconazole, Antifungal, Microparticles, Buccal Tablets, Controlled Release.


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