European Journal of Biomedical and Pharmaceutical Sciences

PROSPECTIVE STUDY OF RELATION OF HELICOBACTER PYLORI IN PATIENTS WITH CHOLELITHIASIS AND DYSPEPSIA

Reeta Kushwaha, Harendra Singh and *Naveen Kushwah

ABSTRACT

Introduction: There are significant number of patients with cholelithiasis do not have post prandial pain but are instead plagued by dyspepsia, vague epigastric discomfort or even mildly increased flatulence as primary manifestation of their biliary stone disease. Such patients are less likely to have a satisfactory outcome following cholecystectomy. This study focuses on the presence of H. Pylori in gastric mucosa of patients with cholelithiasis. Aim of this study is establish the association of Helicobacter pylori in gastric mucosa of patients with cholelithiasis and dyspepsia. Material and Method: This study include the 50 cases of cholelithiasis and post cholecystectomy in the Department of Surgery, J.A. Group of Hospitals, Gwalior. Study includes patients with complaints of dyspepsia, bloating and fullness, abdominal pain, nausea and vomiting. Upper gastrointestinal fiber optic endoscopy was done and examine esophagus stomach and first and second part of the duodenal. Rapid urease test done and biopsy is taken. Urea was present in biopsy and urea split to produce carbon dioxide and ammonia and the colour change from yellow to pink. Demonstration of bacteria by biopsy with hematoxylins and eosin stain. Result: This study found that H. pylori is frequent in patient of cholelithiasis and also in patient with dyspepsia. Dyspepsia seems to act synergistically with helicobacter pylori in gastric pathology. Conclusion: Coexistent Helicobacter pylori and upper gastrointestinal lesions are more common in Indian population as compared to the western statistics. Dietary habits do play a significant role. Females having cholelithiasis are more likely to have upper gastrointestinal associated lesions. H pylori infection was present in 66.66% of patients with endoscopic dyspepsia and 80.76% of patients without endoscopic dyspepsia. that Helicobacter Pylori is frequent in patients of cholelithiasis and also in patient with dyspepsia. Dyspepsia seems to act synergistically with Helicobacter pylori in gastric pathology.

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