Abstract
INTERFERENCE STUDY IN ANALYTICAL METHOD DEVELOPMENT -A CRITICAL REVIEW

Mohammed Asra Khatoon*, Imam Pasha Syed, Anupama Koneru and M. Mushraff Ali Khan

ABSTRACT

The primary focus of this paper is that evaluation criteria of interference in the development of chromatographic methods for separation, identification, and quantification of pharmaceutical compounds, which may be applied within the various functions in the drug development continuum. The paper aims at critical review of forced degradation study & also discusses the issues and parameters that must be considered in the validation of analytical methods. Authors also reviewed the residual solvent analysis and its quantification and significance in the safety, efficacy and potency of pharmaceutical products.

Keywords: Separation, identification, and quantification of pharmaceutical compounds.


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