Abstract
COVID-19 PANDEMIC: NEUROLOGICAL MANIFESTATION, COMPLICATIONS AND FUTURE PROGNOSIS

Yousaf Saeed*, Philip Oreoluwa, Zohaib Farrukh, Nitina Babu, Sonakshi Mirchandani, Amina B. Shah, Cynthia Chioma Anyakorah, Suchitra Muralidharan, Prem Kumar Sah, Rishubh Loei, Prabhnoor Kaur, Sadaf Munir

ABSTRACT

The Severe Acute Respiratory Syndrome Coronavirus Disease-2 (SARS-CoV-2) is the causative agent of coronavirus disease-19 (COVID-19). The World Health Organization has declared this outbreak a pandemic condition, and it has become a public health emergency of international concern. Most of the population is experiencing signs and symptoms similar to the flu and common cold. Despite that, alveolar destruction resulting in progressive lung failure has also been underlined. Although SARS-CoV-2 has been underlined principally to affect the lungs, other system involvement has been described too. Neurological involvement has also been emphasized in the literature. Neurological involvement (central nervous system and peripheral nervous system) in SARS-COV-2 usually corresponds to the following situations: (a) Neurological manifestation of the acute viral infection, (b) neurological manifestations of the post-COVID-19 infection, (c) neurological image of COVID-19 in patients with comorbidities. The actual disease pathogenesis is unknown; however, direct viral invasion of neuronal cells, followed by significant inflammation due to cytokine and inflammatory markers, activation of the complement system, and hypoxia resulting from viral-mediated lung injury leading to oxidative stress, and neuronal cell injury are the proposed mechanisms. Patients with neurological involvement usually experience a wide range of signs and symptoms such as headache, nausea, drowsiness, seizures, altered sensorium, vomiting, and hyposmia. The pandemic of SARS-CoV-2 has become an unprecedented challenge for the physicians and neurologists. Various neurological manifestations have been observed and reported in many cases, and neurological symptoms may precede classical respiratory signs and symptoms. This review summarized the data from published literature, including case reports and open-source data sets to describe the spectrum of neurological manifestations and complications observed in COVID-19 cases.

Keywords: COVID19, SARS-COV-2, neurology, central nervous system, peripheral nervous system.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • NEW OCTOBER ISSUE PUBLISHED

    OCTOBER 2020 Issue has been successfully launched on 1 October 2020.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT