European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW ON BUCCAL DRUG DELIVERY SYSTEM

Pratap Singh*, Gnanarajan and Preeti Kothiyal

ABSTRACT

The Buccal region is rich in blood supply, So the drugs administered in buccal region the patches are design and developed. The buccal mucosa is doing both systemic and local action. The buccal patches are preferred because they enter directly in systemic circulation and avoid hepatic first pass metabolism, due to this bioavailability of drugs are improved. The buccal patches of atenolol is design with hydrophilic polymers like Sodium alginate, Hydroxypropylmethylcellulose, Carbopol 931P, PVP, in their initial proportions and combinations were fabricated by solvent casting technique. The stability studies of patches were done in natural human saliva. Thusthe buccal patches are subject of great interest during recent years because it provides the possibility of avoiding the G.I.T. Contents. About 40% of drugs are lipophilic and failed to reach market due to their poor water solubility.

Keywords: Atenolol, Buccalpatches, Hydrophilicpolymers, Solvent casting method.