HEPATOPROTECTIVE ACTIVITY ON THE COMBINATION OF ANDROGRAPHIS PANICULATA AND SOLANUM NIGRUM ON PARACETAMOL INDUCED HEPATOTOXICITY ON ALBINO RATS
Ram Surat Yadav*, Ashok Kumar Yadav, Rajbahadur, Harikesh Yadav, Bhawna yadav and Pankaj Kumar
ABSTRACT
Measurement of urinary ascorbic acid production, bloodBromsulphthalein clearance, SGPT, SGOT, alkaline phosphatase, serum bilirubin, total proteins, wet liver weight/100 gm body weight, and hepatic lipid peroxidation, superoxide dismutase, glutathione, catalase , and glutathione peroxidase are the appropriate models for the hepatoprotective drug research. Commonly referred to as 'Black nightshade' (Solanaceae), which has been commonly used to treat digestive disorders, chronic skin diseases (psoriasis which ringworm), autoimmune symptoms, painful periods, fevers, eye infections, hydrophobia, etc., in herbal medicine in India and other parts of the world. Compounds of anti-tumor function, such as full alkaloids, steroid alkaloids, steroidal saponins and glycoproteins, have been shown to contain Solanum nigrum. In Indian herbal medicine, the plant is used as a hepatoprotective agent. In this report, we investigated the phyto-pharmacological properties of the Solanum nigrum plant and compiled its detailed pharmacological applications to understand and synthesise the subject of its possible multipurpose image of medicinal agents. Andrographis Paniculata has been used for centuries in India , China, Thailand, and other Asian nations and is present in 26 different polyherbal formulations in the Ayurvedic classical health system. Kalmegh is identified as a cold herb used to eliminate fevers and dissipate toxins from the body in the 1992 Pharmacopoeia of the People's Republic of China. An immunostimulant preparation known as Kan Jang containing Kalmegh and eleutherococcus has been used for 20 years in the Scandinavian countries. In the United States, Kalmegh is produced and marketed as well.
Keywords: hepatotoxicity, Solanum nigrum, Andrographic Paniculata, liver.
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